Brian R Walker Selected Research

11-beta-Hydroxysteroid Dehydrogenases (11beta Hydroxysteroid Dehydrogenase)

6/2010	Modulation of 11beta-hydroxysteroid dehydrogenase type 1 activity by 1,5-substituted 1H-tetrazoles.
3/2009	Therapeutic manipulation of glucocorticoid metabolism in cardiovascular disease.
5/2007	Omental 11beta-hydroxysteroid dehydrogenase 1 correlates with fat cell size independently of obesity.
6/2006	Genetic variation in 11beta-hydroxysteroid dehydrogenase type 1 predicts adrenal hyperandrogenism among lean women with polycystic ovary syndrome.
1/2006	Polymorphisms in the gene encoding 11B-hydroxysteroid dehydrogenase type 1 (HSD11B1) and lifetime cognitive change.
4/2004	Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice.
1/2003	Effects of the 11 beta-hydroxysteroid dehydrogenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes.
11/2002	Acute intrarenal administration of cortisol has no effect on renal blood flow in hypertensive individuals.

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Brian R Walker Research Topics

Disease

66	Obesity 01/2021 - 07/2002
43	Insulin Resistance 08/2021 - 05/2002
24	Metabolic Syndrome (Dysmetabolic Syndrome X) 08/2021 - 07/2002
23	Type 2 Diabetes Mellitus (MODY) 04/2020 - 12/2002
10	Cardiovascular Diseases (Cardiovascular Disease) 06/2021 - 11/2004
10	Glucose Intolerance 01/2021 - 07/2002
10	Birth Weight (Birth Weights) 01/2016 - 09/2002
10	Hypertension (High Blood Pressure) 06/2014 - 12/2002
9	Weight Loss (Weight Reduction) 04/2020 - 02/2004
8	Hyperinsulinism (Hyperinsulinemia) 01/2019 - 01/2003
8	Cushing Syndrome 06/2014 - 10/2003
7	Myocardial Infarction 06/2021 - 08/2005
7	Inflammation (Inflammations) 06/2021 - 01/2007
7	Weight Gain 01/2019 - 04/2003
7	Cognitive Dysfunction 01/2017 - 04/2004
6	Fatty Liver 01/2019 - 10/2003
6	Atherosclerosis 05/2015 - 11/2007
6	Metabolic Diseases (Metabolic Disease) 09/2013 - 11/2006
6	Abdominal Obesity 05/2012 - 07/2002
5	Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal) 01/2020 - 06/2013
5	Critical Illness (Critically Ill) 01/2019 - 03/2010
5	Hyperglycemia 01/2014 - 12/2002
4	Neoplasms (Cancer) 01/2020 - 12/2010
4	Fibrosis (Cirrhosis) 01/2018 - 05/2010
3	Addison Disease (Addison's Disease) 01/2021 - 01/2016
3	Breast Neoplasms (Breast Cancer) 01/2020 - 01/2019
3	Body Weight (Weight, Body) 01/2020 - 09/2006
3	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 04/2019 - 08/2014
3	Alzheimer Disease (Alzheimer's Disease) 01/2017 - 01/2006
3	Adrenal Insufficiency (Adrenal Gland Hypofunction) 12/2016 - 05/2010
3	Starvation 01/2016 - 02/2004
3	Atrophy 08/2014 - 01/2012
2	Thinness 04/2018 - 01/2016
2	Congenital adrenal hyperplasia due to 21 hydroxylase deficiency 12/2017 - 06/2013
2	Hemorrhage 12/2017 - 04/2009
2	Infarction (Infarctions) 01/2016 - 10/2010
2	Heart Failure 01/2016 - 03/2014
2	Hypertrophy 01/2016 - 05/2007
2	Dementia (Dementias) 12/2015 - 02/2015
2	Prostatic Diseases 08/2014 - 08/2014
2	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 07/2014 - 06/2006
2	Fetal Growth Retardation (Intrauterine Growth Retardation) 07/2013 - 09/2002
2	Myocardial Ischemia (Ischemic Heart Diseases) 01/2012 - 04/2010
2	Choline Deficiency 02/2011 - 07/2006
2	Hepatocellular Carcinoma (Hepatoma) 05/2010 - 05/2004

Drug/Important Bio-Agent (IBA)

68	GlucocorticoidsIBA 08/2021 - 07/2002
63	Hydrocortisone (Cortisol)FDA LinkGeneric 08/2021 - 02/2002
30	11-beta-Hydroxysteroid Dehydrogenase Type 1IBA 01/2014 - 07/2002
24	Oxidoreductases (Dehydrogenase)IBA 01/2021 - 02/2004
21	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 01/2003
20	Insulin (Novolin)FDA Link 01/2021 - 04/2003
20	EnzymesIBA 01/2017 - 12/2002
18	Cortisone FDA Link 01/2021 - 02/2002
13	Messenger RNA (mRNA)IBA 01/2016 - 08/2003
11	AndrogensIBA 01/2019 - 10/2003
9	Adrenocorticotropic Hormone (ACTH)FDA Link 11/2018 - 05/2003
8	CorticosteroneIBA 08/2021 - 10/2003
8	Hormones (Hormone)IBA 06/2021 - 02/2006
8	Dexamethasone (Maxidex)FDA LinkGeneric 12/2017 - 01/2003
8	11-beta-Hydroxysteroid Dehydrogenases (11beta Hydroxysteroid Dehydrogenase)IBA 06/2010 - 11/2002
7	LipidsIBA 08/2021 - 01/2003
7	SteroidsIBA 01/2020 - 03/2007
7	Triglycerides (Triacylglycerol)IBA 01/2017 - 12/2002
7	CarbenoxoloneIBA 03/2014 - 01/2003
6	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 08/2014 - 05/2002
5	Nonesterified Fatty Acids (NEFA)IBA 11/2015 - 01/2003
4	Metformin (Glucophage)FDA LinkGeneric 04/2020 - 01/2015
4	Finasteride (Propecia)FDA LinkGeneric 04/2019 - 08/2014
4	Dutasteride (Avodart)FDA Link 04/2019 - 08/2014
4	LeptinIBA 01/2019 - 08/2003
4	(4- (2- chlorophenyl- 4- fluoro- 1- piperidinyl)(5- (1H- pyrazol- 4- yl)- 3- thienyl)methanoneIBA 01/2018 - 03/2014
4	Fatty Acids (Saturated Fatty Acids)IBA 02/2011 - 03/2003
3	CholesterolIBA 08/2021 - 10/2003
3	Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA 01/2021 - 07/2003
3	Estradiol (Delestrogen)FDA LinkGeneric 01/2020 - 01/2016
3	Aromatase (CYP19)IBA 01/2019 - 03/2007
3	Bile Acids and Salts (Bile Acids)IBA 08/2014 - 10/2003
3	Proteins (Proteins, Gene)FDA Link 03/2014 - 01/2005
3	Mifepristone (RU 486)FDA Link 04/2009 - 05/2004
2	Calcium Gluconate (CBG)IBA 06/2021 - 01/2019
2	Carbonyl Reductase (NADPH)IBA 01/2021 - 01/2017
2	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2015
2	Estrone FDA Link 01/2020 - 12/2019
2	Estrogens (Estrogen)FDA Link 01/2020 - 01/2016
2	Hypoglycemic Agents (Hypoglycemics)IBA 04/2018 - 01/2016
2	Thiosulfate Sulfurtransferase (Rhodanese)IBA 04/2018 - 01/2016
2	CollagenIBA 01/2017 - 02/2015
2	Testosterone (Sustanon)FDA Link 01/2016 - 05/2012
2	AldosteroneIBA 03/2014 - 06/2009
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2014 - 10/2003
2	Apolipoproteins E (ApoE)IBA 04/2013 - 02/2011
2	AdipokinesIBA 05/2012 - 05/2005
2	CytokinesIBA 04/2012 - 01/2007
2	Choline (Choline Chloride)IBA 02/2011 - 07/2006
2	PhosphoenolpyruvateIBA 01/2005 - 05/2004

Therapy/Procedure

15	Therapeutics 01/2021 - 07/2002
3	Ligation 02/2011 - 08/2005
2	Caloric Restriction 01/2016 - 02/2004
2	Glycemic Control 04/2012 - 04/2004
2	Carbohydrate-Restricted Diet (Low Carbohydrate Diet) 01/2010 - 11/2007